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     ...External Validation Compounds

CSBBB  External Validation Compounds

Listed below are 20 representative compounds from the CSBBB external validation set

All predicted logBB values were made using CSBBB and the 2D structures of the drugs.  Both the 2D structure and the observed logBB values were taken from the 11 sources listed below. (12-17)

(12) Dolly C. Ed. (1999), Therapeutic Drugs, 2nd Ed, Publ. Churchill Livingstone;  (13) Bouw et al. (2001) British Journal of Pharmacology 134:1796-1804;  (14) Proksch et al. (2000), Drug Metabolism and Disposition, Vol. 28, Issue 7, 742-747;  (15) Rivière et al (2000), Pharmacology, Vol. 292, Issue 3, 1042-1047;  (16) Tai et al. (2001), PNAS, March 13, 2001, vol. 98, no. 6, 3519-3524;  (17) Marston et al. (1998) JPET Vol. 285, Issue 3, 1023-1030.