HIA Representative Compounds

CSHIA

...Representative Compounds

CSHIA External Validation Compounds

Listed below are 30 representative compounds from the CSHIA external validation set

The percent human intestinal absorption (%HIA, oral absorption) values and associated drugs structures used in the generation and testing of the CSHIA predictor were taken from the sources given in the list below. The drugs from different sources with reported values were compared. In the vast majority of cases(98%) reported or used % oral absorption values among the sources were in excellent agreement for drugs undergoing passive transport.

(1) Zhao Y. H. et al, J. Pharm. Sci. 90, 749 (2001)

(2) Zmuidinavicus D. et al, J. Pharm. Sci. 92, 621 (2003)

(3) Klopman G. et al, Eur. J. Pharm. Sci., 17, 253 (2002)

(4) PDF (Physician Desk Reference), Publ. Thompson (2003)

(5) Dolly C. Ed., Therapeutic Drugs, 2nd Ed, Publ. Churchill Livingstone (1999)